Guntur has been politically highly active district in the state. The boundaries of the district are as follows: Eastern and North Eastern – The Krishna River, South East- Bay of Bengal, South- Prakasam District, West- Mahabubnagar District. There are 57 Mandals in the district. Main crops are paddy, chillies, tobacco and cotton. Tobacco barons from Guntur district such as Rayapati Sambasivarao are politically very strong and influential. Politically important places in the district are Guntur, Narasaraopet, Vinukonda, Gurajala, Macherla and Bapatla. Maoists also have their presence in and around Gurajala, Vinukonda, Macherla and Karampudi forest area. Following are present MLAs and MPs from Guntur District:
1. Pedakurapadu: Kommalapati Sreedhar: Telugu Desam
2. Tadikonda: Dokka Manikya Vara Prasada Rao: Congress Party
3. Mangalagiri: Kamala Kandru: Congress Party
4. Ponnur: Dhulipalla Narendra Kumar: Telugu Desam
5. Vemuru: Ananda Babu Nakka: Telugu Desam
6. Repalle: Mopidevi Venkata Ramana Rao: Congress Party
7. Tenali: Nadendla Manohar: Congress Party
8. Bapatla: Gade Venkata Reddy: Congress Party
9. Prathipadu: Sucharitha Mekathoti: Congress Party
10. Guntur West: Kanna Lakshminarayana: Congress Party
11. Guntur East: Shaik Mastan Vali: Congress Party
12. Chilakaluripet: Prathipati Pulla Rao: Telugu Desam
13. Narasaraopet: Kasu Venkata Krishna Reddy: Congress Party
14. Sattenpalli: Yarram Venkateswara Reddy: Congress Party
15. Vinukonda: Gonuguntla Venkata Seeta Ramanjaneyulu: Telugu Desam
16. Guruzala: Yarapathineni Srinivasa Rao: Telugu Desam
17. Macherla: Rama Krishna Reddy Pinnelli: Congress Party
Members of Parliament (MPs):
1. Guntur: Rayapati Sambasiva Rao (Congress Party)
2. Narasaraopet: Modugula Venugopala Reddy (Telugu Desam)
3. Bapatla: Panabaka Lakshmi (Congress Party)