Danam Nagender is a strong leader of the Congress Party in Hyderabad, Andhra Pradesh. He was elected from Asif Nagar Assembly Constituency in 1994, 1999 and 2004 elections. He is a close follower of the late Chief Minister Dr. Y.S. Rajasekhar Reddy. After delimitation of the constituencies, Nagender contested and won from Khairatebad Assembly Constituency in 2009 elections.
Danam Nagender was inducted into the cabinet for the first time by YSR in 2009 and held portfolio of Health and Medical Services and continued in the same portfolio in the cabinet of K. Rosaiah. Danam Nagender showed the 'real' politics after the death of YSR. Once a staunch and die hard follower of YSR, suddenly turned negative on his son Y.S. Jagan Mohan Reddy in pursuit of ministry in the wake of formation of new cabinet by N. Kiran Kumar Reddy in December, 2010. He protested in front of Y.S. Jagan's media house, Sakshi, against the telecast of a programme on Sonai Gandhi and the Congress party. All these efforts were assured him a berth in N. Kiran Kumar Reddy's cabinet with Labour portfolio.
The most funniest part of the Danam Nagender's political life could be his flip flops during 2004 Assembly elections. He left the Congress Party sensing bleak chances of getting a seat due to rift with PCC President D. Srinivas and joined in TDP. After winning from Asifnagar on the TDP ticket, he resigned to the MLA seat and left TDP in an effort to get a berth in YSR cabinet through re-election as an MLA on the Congress ticket. He joined the Congress Party and contested in the bye elections but received a fitting lesson from the voters. He was defeated by the voters for his poli'tricks' and left with nothing but to wait till 2009 elections.
Danam Nagender also been known along with Mukesh Goud for their stand on union territory status for Hyderabad City in the wake of demands for the formation of Separate Telangana. He is not consistent on this issue as well after threats from the supporters of Telangana statehood. Presently, he is President of the Greater Hyderabad Congress Committee and held Ministry of Labour.